With DMAE & MSM that improve the disappearance of sagging skin, frown lines, under-eye bags, firm neck lines, & thin lips. DMAE: a booster that enhances the strength of other antioxidant therapies. Look for this skin care ingredient if you have a problem in a) Loss of firmness in the skin on the face or body b) Fine lines above and below the lips c) Stressed, or overtired skin d) Thin lips that you want to look fuller and more define.
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Direction: Each morning apply liberally on face, lips, neck & décolleté. For best results, apply the Instant Lift Therapeutic Concentrate first BEFORE Instant Lift Therapeutic Serum.
Ingredients: Aloe barbadensis (Organic Aloe Vera) Leaf Juice, Vegetable Glycerin, Dimethylaminoethanol (DMAE), Limnanthes alba (Meadowfoam Seed) Oil, Emulsifying Wax, Methylsulfonylmethane (MSM), Spirulina maxima (Blue Green Algae) Extract, Tocopherol (Vitamin E), Phenoxyethanol, Salix nigra (Black Willowbark) Extract, Rosmarinus officinalis (Rosemary) Oleoresin, Azadirachta indica (Neem) Oil, Xanthan Gum (Polysaccharide Gum), Tetrasodium EDTA, Citric Acid.
DMAE Skin Benefits
FULLER, FIRM ER LIPS: combined with antioxidants, can also help with another beauty dilemma --thin and aging skin around lips. in the right combination, this compound can
actually plump up lips that are too thin or are showing fine lines and wrinkles. Perhaps the best description of how this combination works comes from professional make-up artist Matthew Van Leeuwen. In a recent issue of In Style magazine, he said that he never applies lip color to any of his clients unless he prepares their lips with DMAE (as a lip plumper) first. "It makes lips look as if you just made out for
half an hour," Van Leeuwen says.
Is he imagining? Not at all. Clinical studies show that DMAE actually helps increase circulation and tone to the lips, creating a fuller, firmer appearance.
The Role of DMAE in Cosmetic Dermatology
Skincare formulations for the improvement of aging skin are increasingly important consumer products. Here, we review available data on one such agent – 2-dimethylaminoethanol (DMAE) or deanol – that has recently been evaluated in a placebo-controlled trial. DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine. Although the role of acetylcholine as a neurotransmitter is well known, growing evidence points to acetylcholine as a ubiquitous cytokine-like molecule that regulates basic cellular processes such as proliferation, differentiation, locomotion, and secretion in a paracrine and autocrine fashion. Indeed, this modulatory role may contribute to the cutaneous activity of DMAE. In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious (p < 0.05) in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but ≤ 0.1) were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. Application was found to be well tolerated, with no differences in the incidence of erythema, peeling, dryness, itching, burning, or stinging between the DMAE and placebo groups. An open-label extension of the trial showed that the long-term application of DMAE gel for up to 1 year was associated with a good safety profile. The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. In vitro studies in peripheral blood lymphocytes indicate that DMAE is a moderately active anti-inflammatory agent. Although its mechanisms of action in the skin remain to be elucidated, evidence suggests that the skin is an active site of acetylcholine synthesis, storage, secretion, metabolism, and receptivity. Muscarinic acetylcholine receptors have been localized to keratinocytes, melanocytes and dermal fibroblasts, whereas nicotinic acetylcholine receptors have been found in keratinocytes. The role of acetylcholine and the role of DMAE as a modulator of acetylcholine-mediated functions in the skin remain to be elucidated. Thus, the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone. Studies are needed to evaluate the relative efficacy of DMAE compared with other skin-care regimens (e.g., topical antioxidant creams, α-hydroxy acids).
References:
Grossman, R. (2005). The Role of Dimethylaminoethanol in Cosmetic Dermatology. American Journal Of Clinical Dermatology, 6(1), 39-47.
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